Flibanserin (Oral)

Your healthcare provider will advise you if you should stop breastfeeding or stop Addyi.

• Flibanserin acts as an agonist on dopamine receptors and antagonist on certain serotonin receptors.
• The medication can take several weeks to show benefits.
• It is not approved for use in postmenopausal women.
• Flibanserin was initially developed as an antidepressant.
• It has a pharmacokinetic profile with a half-life of around 13 hours.
• Dose adjustments are necessary for patients with liver impairment.
• The drug can cause hypotension, especially with alcohol or CYP3A4 inhibitors.
• Patients are monitored for side effects such as sleepiness and low blood pressure.
• Flibanserin's efficacy is moderate and varies among women.

For more information about Addyi, you can visit the manufacturer’s website at or call them at 844-PINK-PILL (844-746-5745). You should not eat or drink anything with grapefruit or grapefruit juice in it while taking Addyi.

Side effects

Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information. Overview: Addyi is used in certain women to treat low sex drive (hypoactive sexual desire disorder or HSDD). It seems to work by balancing chemicals in the brain, including dopamine, norepinephrine, and serotonin. Common side effects include nausea, sleepiness, and dizziness.

Clinical Uses

Serious side effects are rare, but can include low blood pressure and fainting. It is important to tell your healthcare provider about all of the medicines you take before and while taking Addyi. Addyi (flibanserin) is commonly used to treat low sex drive (hypoactive sexual desire disorder or HSDD) in women less than 65 years of age who have not had problems with low sexual desire in the past and have low sexual desire no matter the type of sexual activity or partner. It is not for people whose low sex drive is caused by medical or mental health problems, relationship problems, or medicines or drug use. Addyi may also be used for other conditions as determined by your healthcare provider. Grapefruit can increase blood levels of Addyi in your body and increase your risk of low blood pressure and fainting.

Aspect	Details
Chemical Formula	C_20H_21F_3N_4O
Molecular Weight	370.41 g/mol
Key Functional Groups	Triazole ring, fluorinated phenyl group
Structural Type	Non-steroidal compound

Alcohol can increase your risk of low blood pressure and fainting with Addyi.

Side Effect	Incidence	Recommendations
Hypotension	Rare	Monitor blood pressure
Syncope	Rare	Avoid alcohol and sedatives
Severe Allergic Reactions	Very rare	Immediate medical intervention

You should wait at least two hours after drinking two or fewer standard alcoholic drinks before taking Addyi at bedtime.

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If you have had three or more drinks with alcohol in them, you should skip your dose of Addyi that evening.

Availability and cost

Addyi seems to work by balancing brain chemicals that affect sex drive, such as dopamine, norepinephrine, and serotonin. Addyi should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. The most common side effects of Addyi are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

What should I tell my healthcare provider before using Addyi?

There may be other side effects of Addyi that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345. While less common, the most serious side effects of Addyi are described below, along with what to do if they happen. Once you have taken Addyi in the evening, you should not drink any alcohol until at least the next day.

What special precautions should I follow?

It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof.

Serious Adverse Effects

The use of this information is governed by the Terms of Use, available at The exact mechanism of action of flibanserin is unknown. Here is basic information about this medication. Treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: A co-existing medical or psychiatric condition The effects of a medication or other drug substance Recommended: 100 mg orally taken once daily at bedtime Discontinue treatment after 8 weeks if no improvement Moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors Please refer to the full Prescribing Information (see link below) before prescribing this medication. Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons or as a substitute for medical advice, diagnosis, or treatment. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Addyi (flibanserin) contraindications

Addyi may cause allergic reactions, which can be serious. Stop taking Addyi and get help right away if you have any of the following symptoms of a serious allergic reaction. Swelling of the face, lips, mouth, tongue, or throat Itching, skin rash, or pale red bumps on the skin called hives Addyi may slow down your central nervous system (CNS), which controls many vital functions throughout the body. Call your healthcare provider right away if you have any of the following symptoms of CNS depression. Addyi can affect your alertness or coordination.

Key Takeaways

Do not drive or sex for man tablet do other activities that require alertness or coordination for at least six hours after taking Addyi and until you know how Addyi affects you. If you feel faint or dizzy, lie down. The risk of low blood pressure or fainting can be increased if you drink alcohol or take certain medicines with Addyi. Tell your healthcare provider right away if you have any of the following symptoms of low blood pressure. People who are allergic to any of the following should not take Addyi. In particular, make sure that you discuss if you are using any of the following before taking Addyi.

Overdose/Missed Dose

Any of the ingredients in the specific product dispensed Your pharmacist can tell you all of the ingredients in Addyi. Addyi should not be taken while you are using certain other medicines. Before taking Addyi, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details. Addyi should not be taken if your liver is not working as well as it should be.

How is this drug best taken?

If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine. Do not take Addyi unless it has been prescribed to you by a healthcare provider. Do not share Addyi with other people, even if they have the same condition as you. Keep Addyi out of the reach of children. This may decrease your risk for fainting, because you will be lying down already. Any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety Ketoconazole, itraconazole (Sporanox, Tolsura), posaconazole

IMPORTANT WARNING:

If you have been taking Addyi for eight weeks or more and it is not improving your symptoms, tell your healthcare provider. Your healthcare provider may advise you to stop taking it. Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Addyi is right for you. In particular, make sure that you discuss any of the following.

Activity profile

Tell your healthcare provider if you have any of the following. Drink alcohol or use drugs, including a history of drug or alcohol misuse Current or history of mental health problems, including depression It is not known if or how Addyi could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. It is not known if Addyi passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. (Noxafil), fluconazole (Diflucan), or voriconazole (Vfend), which is a medicine used for fungal infections Clarithromycin, erythromycin, or ciprofloxacin, which is an antibiotic used for bacterial

• Flibanserin was developed by Boehringer Ingelheim, later licensed to Sprout Pharmaceuticals.
• It is considered a "female Viagra," though its mechanism differs from male erectile drugs.
• The medication is part of the growing field of female sexual dysfunction treatment.
• Most clinical trials showed a modest increase in satisfying sexual events.
• Flibanserin should be taken consistently for best results.
• It is not recommended for women who are pregnant or breastfeeding.
• Common adverse reactions include dry mouth and insomnia.
• The drug was approved after extensive clinical trials involving thousands of women.
• Long-term safety data is still being collected.

infections Diltiazem (Cardizem CD and others) or verapamil (Verelan, Verelan PM), which is a medicine used for high blood pressure and other conditions Any medicine for seizures, such as carbamazepine, phenytoin, or phenobarbital A selective serotonin reuptake inhibitor (SSRI), such as fluoxetine, paroxetine, or sertraline, which is a medicine commonly

Country	Approval Status	Year
United States	Approved	2015
Canada	Approved	2016
European Union	Pending/Under review	N/A
Australia	Not approved	N/A

used for anxiety and depression A medicine for HIV, AIDS, or hepatitis C Cimetidine, ranitidine, or a proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex) Rifampin (Rifadin) or rifapentine (Priftin), which is a medicine commonly used to treat an infection called

• Direct comparison trials between flibanserin and bremelanotide are lacking.
• Choice of treatment depends on patient preference, risk profile, and cost.
• Psychological and interpersonal factors are important contributors to HSDD.
• Combining medication with sex therapy or counseling may improve outcomes.
• Flibanserin does not increase libido in individuals without HSDD.
• It is not approved or intended for use as a recreational or enhancement drug.
• Off-label use, such as in postmenopausal women or men, is not supported by evidence.
• Healthcare providers must complete an online knowledge assessment for REMS certification.
• Certification must be renewed periodically according to the REMS program.

tuberculosis Rifabutin (Mycobutin), which is a medicine used to prevent Mycobacterium avium complex infection Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure Nefazodone, which is used to treat depression Conivaptan (Vaprisol), which is used to treat low blood sodium levels St.

The Clinically Proven Treatment for Low Sexual Desire

Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider. This drug comes with an extra patient fact sheet called a Medication Guide. Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider.

Mona Gupta, DO

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient.

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